{"id":21289,"date":"2024-08-01T13:48:59","date_gmt":"2024-08-01T13:48:59","guid":{"rendered":"https:\/\/site-euspringworks-live-1721707192-jq9cikhfcu2uwhr.local\/diagnostic\/"},"modified":"2025-07-30T07:34:03","modified_gmt":"2025-07-30T07:34:03","slug":"diagnostic","status":"publish","type":"page","link":"https:\/\/www.desmoidtumours.eu\/fr\/diagnostic\/","title":{"rendered":"Diagnostic"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"21289\" class=\"elementor elementor-21289 elementor-20166\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9152995 e-flex e-con-boxed e-con e-parent\" data-id=\"9152995\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-de1bdb6 elementor-widget elementor-widget-spacer\" data-id=\"de1bdb6\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-20a8237f the7-e-sticky-row-yes e-flex e-con-boxed e-con e-parent\" data-id=\"20a8237f\" data-element_type=\"container\" id=\"sub-nav-bar\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;the7_sticky_row&quot;:&quot;yes&quot;,&quot;the7_sticky_row_offset&quot;:116,&quot;the7_sticky_row_offset_tablet_extra&quot;:60,&quot;the7_sticky_row_offset_tablet&quot;:50,&quot;the7_sticky_row_offset_mobile&quot;:60,&quot;the7_sticky_row_devices&quot;:[&quot;desktop&quot;,&quot;laptop&quot;,&quot;tablet_extra&quot;,&quot;tablet&quot;,&quot;mobile&quot;]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-17c10cd2 e-con-full e-flex e-con e-child\" data-id=\"17c10cd2\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-305c1c24 elementor-widget elementor-widget-text-editor\" data-id=\"305c1c24\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><a href=\"#guidelines-recommendations\">Recommandations des lignes directrices<\/a><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1fa35116 e-con-full e-flex e-con e-child\" data-id=\"1fa35116\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-76ba3586 elementor-widget elementor-widget-text-editor\" data-id=\"76ba3586\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><a href=\"#differential-diagnosis\">Diagnostic diff\u00e9rentiel<\/a><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-574ab19d e-con-full e-flex e-con e-child\" data-id=\"574ab19d\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-74fe7b8e elementor-widget elementor-widget-text-editor\" data-id=\"74fe7b8e\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><a href=\"#diagnostic-strategies\">Strat\u00e9gies de diagnostiques<\/a><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7ffc003c e-con-full e-flex e-con e-parent\" data-id=\"7ffc003c\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-3707e425 e-flex e-con-boxed e-con e-child\" data-id=\"3707e425\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e0bc626 elementor-widget elementor-widget-heading\" data-id=\"e0bc626\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Diagnostic<\/h1>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-72166f9 e-con-full section e-flex e-con e-parent\" data-id=\"72166f9\" data-element_type=\"container\" id=\"guidelines-recommendations\">\n\t\t<div class=\"elementor-element elementor-element-fad0ebe e-flex e-con-boxed e-con e-child\" data-id=\"fad0ebe\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-f749dd1 e-con-full e-flex e-con e-child\" data-id=\"f749dd1\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-dd5ee8e e-con-full e-flex e-con e-child\" data-id=\"dd5ee8e\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3307b47 elementor-widget-tablet__width-inherit elementor-widget elementor-widget-the7-heading\" data-id=\"3307b47\" data-element_type=\"widget\" data-widget_type=\"the7-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"the7-heading-title elementor-size-default\">Recommandations des lignes directrices<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0b99779 elementor-widget-tablet__width-inherit elementor-widget elementor-widget-the7-heading\" data-id=\"0b99779\" data-element_type=\"widget\" data-widget_type=\"the7-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"the7-heading-title elementor-size-default\">Une collaboration avec des sp\u00e9cialistes peut am\u00e9liorer le pronostic et la qualit\u00e9 de vie des patients<sup>1,2<\/sup><\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-204ba23 e-con-full e-flex e-con e-child\" data-id=\"204ba23\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-62a4669 elementor-widget-tablet__width-inherit elementor-widget elementor-widget-the7-heading\" data-id=\"62a4669\" data-element_type=\"widget\" data-widget_type=\"the7-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h5 class=\"the7-heading-title elementor-size-default\">Lignes directrices du DTWG<sup>\u2020*<\/sup><\/h5>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-efd3815 elementor-widget-tablet__width-inherit elementor-widget elementor-widget-text-editor\" data-id=\"efd3815\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><em><strong>\u00ab\u00a0Il est recommand\u00e9 de faire appel \u00e0 des \u00e9quipes pluridisciplinaires exp\u00e9riment\u00e9es au moment du diagnostic initial, pour obtenir les meilleurs conseils sur la s\u00e9curit\u00e9 d\u2019une strat\u00e9gie d&rsquo;observation initiale<sup>3<\/sup>\u00a0\u00bb.<\/strong><\/em><\/p><p><em><strong>\u00ab\u00a0La prise en charge des tumeurs desmo\u00efdes est complexe et<br \/>devrait \u00eatre effectu\u00e9e exclusivement dans les centres de r\u00e9f\u00e9rence sp\u00e9cialis\u00e9s dans les tumeurs desmo\u00efdes, avec des r\u00e9unions de concertation pluridisciplinaires<sup>*4<\/sup>\u00a0\u00bb.<\/strong><\/em><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0f4f410 elementor-widget-tablet__width-inherit elementor-widget elementor-widget-text-editor\" data-id=\"0f4f410\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<sup>\u2020<\/sup>&nbsp;Le DTWG regroupe plus de 50&nbsp;sp\u00e9cialistes du sarcome issus de diff\u00e9rentes disciplines, ainsi que des patients et des associations de patients d\u2019Europe, d\u2019Am\u00e9rique du Nord et du Japon<sup>3<\/sup>.<br><sup>*<\/sup>&nbsp;Afin de mettre \u00e0 jour les lignes directrices mondiales de 2020 fond\u00e9es sur des donn\u00e9es probantes pour la prise en charge des patients atteints d\u2019une tumeur desmo\u00efde, le Groupe de travail sur les tumeurs desmo\u00efdes (DTWG) a tenu une r\u00e9union en 2023, o\u00f9 il a d\u00e9gag\u00e9 un consensus sur les principaux aspects de la prise en charge des patients atteints d\u2019une tumeur desmo\u00efde<sup>4<\/sup>.\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-e412980 e-con-full e-flex e-con e-child\" data-id=\"e412980\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5a53d16 elementor-widget-tablet__width-inherit elementor-widget elementor-widget-the7-heading\" data-id=\"5a53d16\" data-element_type=\"widget\" data-widget_type=\"the7-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h5 class=\"the7-heading-title elementor-size-default\">Sarcomes des tissus mous et visc\u00e9raux selon l\u2019ESMO&nbsp;: lignes directrices de pratique clinique de l\u2019ESMO-EURACAN-GENTURIS<\/h5>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d41feed elementor-widget-tablet__width-inherit elementor-widget elementor-widget-text-editor\" data-id=\"d41feed\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><em><strong>\u00ab&nbsp;Le diagnostic pathologique doit \u00eatre pos\u00e9 par un anatomopathologiste sp\u00e9cialiste des sarcomes<sup>5<\/sup>&nbsp;\u00bb.<\/strong><\/em><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3a1e296 e-con-full e-flex e-con e-child\" data-id=\"3a1e296\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-cb36f04 elementor-widget-tablet__width-inherit elementor-widget elementor-widget-the7-heading\" data-id=\"cb36f04\" data-element_type=\"widget\" data-widget_type=\"the7-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h5 class=\"the7-heading-title elementor-size-default\">Lignes directrices du NCCN<\/h5>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-27c54fa elementor-widget-tablet__width-inherit elementor-widget elementor-widget-text-editor\" data-id=\"27c54fa\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><em><strong>\u00ab&nbsp;Avant le d\u00e9but du plan de traitement, tous les patients doivent \u00eatre \u00e9valu\u00e9s et trait\u00e9s par une \u00e9quipe pluridisciplinaire ayant l\u2019expertise et l\u2019exp\u00e9rience des tumeurs desmo\u00efdes<sup>6<\/sup>&nbsp;\u00bb.<\/strong><\/em><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7464f97 e-con-full section e-flex e-con e-parent\" data-id=\"7464f97\" data-element_type=\"container\" id=\"differential-diagnosis\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-9f6bea4 e-flex e-con-boxed e-con e-child\" data-id=\"9f6bea4\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-17e311b e-con-full e-flex e-con e-child\" data-id=\"17e311b\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-a2a6bca e-con-full e-flex e-con e-child\" data-id=\"a2a6bca\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-48f98a4 elementor-widget-tablet__width-inherit elementor-widget elementor-widget-the7-heading\" data-id=\"48f98a4\" data-element_type=\"widget\" data-widget_type=\"the7-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"the7-heading-title elementor-size-default\">Diagnostic diff\u00e9rentiel<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a4c153f elementor-widget-tablet__width-inherit elementor-widget elementor-widget-the7-heading\" data-id=\"a4c153f\" data-element_type=\"widget\" data-widget_type=\"the7-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"the7-heading-title elementor-size-default\">L\u2019obtention d\u2019un diagnostic pr\u00e9cis et rapide demeure un d\u00e9fi<sup>7<\/sup>.<\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b2027ab elementor-widget-tablet__width-inherit bullet-custom elementor-widget elementor-widget-text-editor\" data-id=\"b2027ab\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Les erreurs de diagnostic sont fr\u00e9quentes dans les maladies rares telles que les tumeurs desmo\u00efdes<sup>7<\/sup>.<\/p><ul><li><strong>30 \u00e0 40&nbsp;%<\/strong> des cas de tumeurs desmo\u00efdes auraient \u00e9t\u00e9 mal diagnostiqu\u00e9s \u00e0 la suite d\u2019une analyse histologique<sup>7<\/sup>.<\/li><li>Le diagnostic diff\u00e9rentiel est vaste, et inclut les prolif\u00e9rations fibroblastiques\/myofibroblastiques b\u00e9nignes et malignes, notamment<sup>8<\/sup>&nbsp;:<ul><li>Les cicatrices hypertrophiques<\/li><li>Les ch\u00e9lo\u00efdes et fasciites nodulaires<\/li><li>Le sarcome fibromyxo\u00efde de bas grade<\/li><li>Le sarcome myofibroblastique de bas grade<\/li><\/ul><\/li><li>Les tumeurs de la gaine nerveuse telles que le schwannome, le neurofibrome, le p\u00e9rineuriome et les tumeurs des muscles lisses telles que les l\u00e9iomyomes peuvent \u00e9galement faire l&rsquo;objet d&rsquo;un diagnostic diff\u00e9rentiel<sup>8<\/sup>.<\/li><li>Le sarcome fibromyxo\u00efde de bas grade repr\u00e9sente le diagnostic diff\u00e9rentiel le plus difficile, car il peut pr\u00e9senter un chevauchement morphologique important avec les tumeurs desmo\u00efdes<sup>8<\/sup>.<\/li><li>La tumeur stromale gastro-intestinale (GIST) est un autre diagnostic diff\u00e9rentiel important li\u00e9 aux tumeurs desmo\u00efdes intra\u2010abdominales. Certains cas de tumeurs desmo\u00efdes peuvent pr\u00e9senter une expression faible et focalis\u00e9e de la mutation <em>KIT<\/em><sup>8<\/sup>.<\/li><\/ul><p>Un diagnostic pr\u00e9cis reste crucial pour planifier le traitement de mani\u00e8re appropri\u00e9e<sup>8<\/sup>.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-5a6bdef e-con-full section e-flex e-con e-parent\" data-id=\"5a6bdef\" data-element_type=\"container\" id=\"diagnostic-strategies\">\n\t\t<div class=\"elementor-element elementor-element-db3c6a3 e-flex e-con-boxed e-con e-child\" data-id=\"db3c6a3\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-0cb45ca e-con-full e-flex e-con e-child\" data-id=\"0cb45ca\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-0c069ba elementor-widget-tablet__width-inherit elementor-widget elementor-widget-the7-heading\" data-id=\"0c069ba\" data-element_type=\"widget\" data-widget_type=\"the7-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"the7-heading-title elementor-size-default\">Strat\u00e9gies diagnostiques<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-06a8980 elementor-widget-tablet__width-inherit elementor-widget elementor-widget-the7-heading\" data-id=\"06a8980\" data-element_type=\"widget\" data-widget_type=\"the7-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"the7-heading-title elementor-size-default\">Le diagnostic n\u00e9cessite un examen des ant\u00e9c\u00e9dents m\u00e9dicaux et un examen physique, une imagerie et une biopsie, ainsi qu\u2019une \u00e9valuation histopathologique<sup>7<\/sup>.<\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-41c7149 elementor-widget-tablet__width-inherit elementor-widget elementor-widget-text-editor\" data-id=\"41c7149\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Le diagnostic des tumeurs desmo\u00efdes doit \u00eatre confirm\u00e9 par un anatomopathologiste sp\u00e9cialiste des tissus mous<sup>8<\/sup>.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a4694fc no-link bullet-custom content-align-left icon-box-vertical-align-top icon-position-left icon-vertical-align-start elementor-widget elementor-widget-the7_icon_box_grid_widget\" data-id=\"a4694fc\" data-element_type=\"widget\" data-widget_type=\"the7_icon_box_grid_widget.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div class=\"the7-box-grid-wrapper the7-elementor-widget loading-effect-none the7_icon_box_grid_widget-a4694fc\">\t\t\t<div class=\"dt-css-grid\">\n\t\t\t\t\t\t\t\t\t<div class=\"wf-cell shown\">\n\t\t\t\t\t\t<div class=\"the7-icon-box-grid\">\t\t\t\t\t\t\t<div class=\"box-content-wrapper\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-icon-div\" aria-label=\"Imagerie\">\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-icon\">\n\t\t\t\t\t\t\t\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"186\" height=\"186\" viewBox=\"0 0 186 186\" fill=\"none\"><g clip-path=\"url(#clip0_316_1048)\"><g clip-path=\"url(#clip1_316_1048)\"><path opacity=\"0.3\" d=\"M173.66 12.22C157.36 -4.08 130.95 -4.08 114.65 12.22C108.36 18.51 104.56 26.3 103.13 34.43C103.09 34.62 103.03 34.75 102.99 34.93C98.6599 57.59 103.65 73.86 75.0599 102.46C46.4599 131.05 42.7899 123.43 19.2599 131.29L19.3399 131.38C15.2799 132.7 11.4299 134.86 8.19994 138.08C-2.73006 149.02 -2.73006 166.74 8.19994 177.67C19.1399 188.61 36.8599 188.61 47.7899 177.67C51.0199 174.44 53.1799 170.59 54.4999 166.53L54.5899 166.61C62.4499 143.07 54.8299 139.41 83.4199 110.81C112.01 82.21 128.29 87.2 150.95 82.88C151.14 82.85 151.26 82.78 151.44 82.74C159.58 81.31 167.38 77.5 173.66 71.21C189.96 54.92 189.96 28.5 173.66 12.2\" fill=\"#05C0DA\"><\/path><path d=\"M109.84 137.97C125.28 137.97 137.8 117.81 137.8 92.9501C137.8 68.08 125.28 47.9301 109.84 47.9301C97.33 47.9301 86.74 61.1601 83.17 79.4001\" fill=\"white\"><\/path><path d=\"M109.84 47.92H136.41C151.85 47.92 164.37 68.08 164.37 92.94C164.37 117.81 151.85 137.96 136.41 137.96H109.84H86.0601\" fill=\"white\"><\/path><path d=\"M126.24 101.09H27.8501C25.0701 101.09 22.8201 103.34 22.8201 106.12C22.8201 108.9 25.0701 111.15 27.8501 111.15H80.4501H112.8\" fill=\"white\"><\/path><path d=\"M101.2 90.51C94.0901 89.13 89.9701 83.04 72.5501 85.82C67.1001 86.69 62.8601 92.94 39.1401 92.94C34.0701 92.94 34.0201 97.53 34.0701 100.62\" fill=\"white\"><\/path><path d=\"M91.22 93.6901H77.52C75.32 93.8701 74.03 94.5801 73.87 96.5901C73.71 98.6001 75.11 100.92 76.99 101.09H97\" fill=\"white\"><\/path><path d=\"M110.11 101.09C114.55 101.09 118.15 97.58 118.15 93.24C118.15 88.91 114.4 86.53 110.11 85.4C103.82 83.74 100.56 85.9 100.56 95.33\" fill=\"white\"><\/path><path d=\"M46.22 129.03C43.83 129.03 41.89 127.03 41.89 124.56C41.89 122.09 43.83 120.09 46.22 120.09H86.06C88.45 120.09 90.39 122.09 90.39 124.56C90.39 127.03 88.45 129.03 86.06 129.03H46.22Z\" fill=\"white\"><\/path><path d=\"M46.22 137.97C43.83 137.97 41.89 135.97 41.89 133.5C41.89 131.03 43.83 129.03 46.22 129.03H86.06C88.45 129.03 90.39 131.03 90.39 133.5C90.39 135.97 88.45 137.97 86.06 137.97H46.22Z\" fill=\"white\"><\/path><path d=\"M46.22 120.1C43.83 120.1 41.89 118.1 41.89 115.63C41.89 113.16 43.83 111.16 46.22 111.16H86.06C88.45 111.16 90.39 113.16 90.39 115.63C90.39 118.1 88.45 120.1 86.06 120.1H46.22Z\" fill=\"white\"><\/path><path d=\"M99.21 118.44C102.11 123.09 105.82 125.88 109.88 125.88C119.21 125.88 126.77 111.13 126.77 92.94C126.77 74.75 119.21 60 109.88 60C102.67 60 96.51 68.82 94.09 81.23\" fill=\"white\"><\/path><path d=\"M109.84 137.97C125.28 137.97 137.8 117.81 137.8 92.9501C137.8 68.08 125.28 47.9301 109.84 47.9301C97.33 47.9301 86.74 61.1601 83.17 79.4001\" stroke=\"#005EA7\" stroke-width=\"3.52\" stroke-miterlimit=\"10\"><\/path><path d=\"M109.84 47.92H136.41C151.85 47.92 164.37 68.08 164.37 92.94C164.37 117.81 151.85 137.96 136.41 137.96H109.84H86.0601\" stroke=\"#005EA7\" stroke-width=\"3.52\" stroke-miterlimit=\"10\"><\/path><path d=\"M126.24 101.09H27.8501C25.0701 101.09 22.8201 103.34 22.8201 106.12C22.8201 108.9 25.0701 111.15 27.8501 111.15H80.4501H112.8\" stroke=\"#005EA7\" stroke-width=\"3.52\" stroke-miterlimit=\"10\"><\/path><path d=\"M21.52 137.97H58.78\" stroke=\"#005EA7\" stroke-width=\"3.52\" stroke-miterlimit=\"10\"><\/path><path d=\"M101.2 90.51C94.0901 89.13 89.9701 83.04 72.5501 85.82C67.1001 86.69 62.8601 92.94 39.1401 92.94C34.0701 92.94 34.0201 97.53 34.0701 100.62\" stroke=\"#005EA7\" stroke-width=\"3.52\" stroke-miterlimit=\"10\"><\/path><path d=\"M91.22 93.6901H77.52C75.32 93.8701 74.03 94.5801 73.87 96.5901C73.71 98.6001 75.11 100.92 76.99 101.09H97\" stroke=\"#005EA7\" stroke-width=\"3.52\" stroke-miterlimit=\"10\"><\/path><path d=\"M110.11 101.09C114.55 101.09 118.15 97.58 118.15 93.24C118.15 88.91 114.4 86.53 110.11 85.4C103.82 83.74 100.56 85.9 100.56 95.33\" stroke=\"#005EA7\" stroke-width=\"3.52\" stroke-miterlimit=\"10\"><\/path><path d=\"M46.22 129.03C43.83 129.03 41.89 127.03 41.89 124.56C41.89 122.09 43.83 120.09 46.22 120.09H86.06C88.45 120.09 90.39 122.09 90.39 124.56C90.39 127.03 88.45 129.03 86.06 129.03H46.22Z\" stroke=\"#005EA7\" stroke-width=\"3.52\" stroke-miterlimit=\"10\"><\/path><path d=\"M46.22 137.97C43.83 137.97 41.89 135.97 41.89 133.5C41.89 131.03 43.83 129.03 46.22 129.03H86.06C88.45 129.03 90.39 131.03 90.39 133.5C90.39 135.97 88.45 137.97 86.06 137.97H46.22Z\" stroke=\"#005EA7\" stroke-width=\"3.52\" stroke-miterlimit=\"10\"><\/path><path d=\"M46.22 120.1C43.83 120.1 41.89 118.1 41.89 115.63C41.89 113.16 43.83 111.16 46.22 111.16H86.06C88.45 111.16 90.39 113.16 90.39 115.63C90.39 118.1 88.45 120.1 86.06 120.1H46.22Z\" stroke=\"#005EA7\" stroke-width=\"3.52\" stroke-miterlimit=\"10\"><\/path><path d=\"M99.21 118.44C102.11 123.09 105.82 125.88 109.88 125.88C119.21 125.88 126.77 111.13 126.77 92.94C126.77 74.75 119.21 60 109.88 60C102.67 60 96.51 68.82 94.09 81.23\" stroke=\"#005EA7\" stroke-width=\"3.52\" stroke-miterlimit=\"10\"><\/path><\/g><\/g><defs><clipPath id=\"clip0_316_1048\"><rect width=\"186\" height=\"186\" fill=\"white\"><\/rect><\/clipPath><clipPath id=\"clip1_316_1048\"><rect width=\"185.89\" height=\"185.89\" fill=\"white\"><\/rect><\/clipPath><\/defs><\/svg>\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/a>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"box-content\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<h5 class=\"box-heading\">\n\t\t\t\t\t\t\t\t\t\t\t<a aria-label=\"Imagerie\">\t\t\t\t\t\t\t\t\t\t\t\tImagerie\t\t\t\t\t\t\t\t\t\t\t<\/a>\t\t\t\t\t\t\t\t\t\t<\/h5>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"box-description\"><p>L\u2019\u00e9chographie peut \u00eatre utilis\u00e9e comme imagerie de premi\u00e8re intention, mais s\u2019il y a suspicion d\u2019un sarcome des tissus mous (STM), elle devrait \u00eatre suivie par un examen au scanner ou par une imagerie par r\u00e9sonance magn\u00e9tique (IRM)<sup>5<\/sup>.<\/p>\n\n<p>Dans les tumeurs des tissus mous primaires, l\u2019IRM est la principale modalit\u00e9 d\u2019imagerie des extr\u00e9mit\u00e9s, du bassin et du tronc<sup>5<\/sup>.<\/p>\n\n<p>Les radiographies standard peuvent \u00eatre utiles pour exclure une tumeur osseuse, pour d\u00e9tecter l\u2019\u00e9rosion osseuse avec un risque de fracture et pour montrer des calcifications<sup>5<\/sup>.<\/p>\n\n<p>Le scanner peut exclure une myosite ossifiante dans les cas de l\u00e9sions calcifi\u00e9es, et joue un r\u00f4le dans les sarcomes pleuropulmonaires et les sarcomes r\u00e9trop\u00e9riton\u00e9aux (SRP), o\u00f9 le rendement est identique \u00e0 l\u2019IRM<sup>5<\/sup>.<\/p> \n\n<p>Les caract\u00e9ristiques \u00e0 risque \u00e9lev\u00e9 devraient \u00eatre v\u00e9rifi\u00e9es par biopsie<sup>9<\/sup>&nbsp;:<\/p>\n<ul>\n<li>Augmentation r\u00e9cente de la taille<\/li>\n<li>Localisation profonde par rapport au fascia<\/li>\n<li>Taille &gt; 4&nbsp;cm<\/li>\n<li>Mod\u00e8les de croissance invasifs observ\u00e9s en imagerie<\/li>\n<\/ul>\n<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"wf-cell shown\">\n\t\t\t\t\t\t<div class=\"the7-icon-box-grid\">\t\t\t\t\t\t\t<div class=\"box-content-wrapper\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-icon-div\" aria-label=\"Biopsie et coloration nucl\u00e9aire de la \u03b2-cat\u00e9nine\">\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-icon\">\n\t\t\t\t\t\t\t\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"186\" height=\"186\" viewBox=\"0 0 186 186\" fill=\"none\"><g clip-path=\"url(#clip0_316_1047)\"><g clip-path=\"url(#clip1_316_1047)\"><path opacity=\"0.3\" d=\"M173.66 12.22C157.36 -4.08 130.95 -4.08 114.65 12.22C108.36 18.51 104.56 26.3 103.13 34.43C103.09 34.62 103.03 34.75 102.99 34.93C98.6599 57.59 103.65 73.86 75.0599 102.46C46.4599 131.05 42.7899 123.43 19.2599 131.29L19.3399 131.38C15.2799 132.7 11.4299 134.86 8.19994 138.08C-2.73006 149.02 -2.73006 166.74 8.19994 177.67C19.1399 188.61 36.8599 188.61 47.7899 177.67C51.0199 174.44 53.1799 170.59 54.4999 166.53L54.5899 166.61C62.4499 143.07 54.8299 139.41 83.4199 110.81C112.01 82.21 128.29 87.2 150.95 82.88C151.14 82.85 151.26 82.78 151.44 82.74C159.58 81.31 167.38 77.5 173.66 71.21C189.96 54.92 189.96 28.5 173.66 12.2\" fill=\"#05C0DA\"><\/path><path d=\"M147.796 55.8709L130.027 38.1013L100.484 67.6442L118.253 85.4138L147.796 55.8709Z\" fill=\"white\" stroke=\"#005EA7\" stroke-width=\"3.52\" stroke-miterlimit=\"10\"><\/path><path d=\"M114.214 81.3812L104.52 71.6868L94.8251 81.3812L104.52 91.0756L114.214 81.3812Z\" fill=\"white\" stroke=\"#005EA7\" stroke-width=\"3.52\" stroke-miterlimit=\"10\"><\/path><path d=\"M99.67 86.22L25.98 159.91\" stroke=\"#005EA7\" stroke-width=\"3.52\" stroke-miterlimit=\"10\"><\/path><path d=\"M109.17 58.96L103.01 52.8C98.78 48.57 98.78 41.71 103.01 37.48C107.24 33.25 114.1 33.25 118.34 37.48L124.5 43.64\" stroke=\"#005EA7\" stroke-width=\"3.52\" stroke-miterlimit=\"10\"><\/path><path d=\"M142.26 61.4L148.42 67.56C152.65 71.79 152.65 78.65 148.42 82.89C144.19 87.12 137.33 87.12 133.09 82.89L126.93 76.73\" stroke=\"#005EA7\" stroke-width=\"3.52\" stroke-miterlimit=\"10\"><\/path><path d=\"M155.889 39.6908L146.195 29.9963L134.061 42.1303L143.755 51.8247L155.889 39.6908Z\" fill=\"white\" stroke=\"#005EA7\" stroke-width=\"3.52\" stroke-miterlimit=\"10\"><\/path><path d=\"M165.91 49.71L136.18 19.98\" stroke=\"#005EA7\" stroke-width=\"3.52\" stroke-miterlimit=\"10\"><\/path><\/g><\/g><defs><clipPath id=\"clip0_316_1047\"><rect width=\"186\" height=\"186\" fill=\"white\"><\/rect><\/clipPath><clipPath id=\"clip1_316_1047\"><rect width=\"185.89\" height=\"185.89\" fill=\"white\"><\/rect><\/clipPath><\/defs><\/svg>\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/a>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"box-content\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<h5 class=\"box-heading\">\n\t\t\t\t\t\t\t\t\t\t\t<a aria-label=\"Biopsie et coloration nucl\u00e9aire de la \u03b2-cat\u00e9nine\">\t\t\t\t\t\t\t\t\t\t\t\tBiopsie et coloration nucl\u00e9aire de la \u03b2-cat\u00e9nine\t\t\t\t\t\t\t\t\t\t\t<\/a>\t\t\t\t\t\t\t\t\t\t<\/h5>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"box-description\"><p>Apr\u00e8s une \u00e9valuation appropri\u00e9e par imagerie, l\u2019approche standard dudiagnostic consiste \u00e0 pr\u00e9lever plusieurs biopsies, en utilisant au besoin des aiguilles de \u2265 14 \u00e0 16 G.<sup>5<\/sup>.<\/p>\n\n<p>Une biopsie excisionnelle peut \u00eatre l\u2019option la plus pratique pour les l\u00e9sions superficielles &lt; 3&nbsp;cm. Une biopsie ouverte peut \u00eatre une alternative dans certains cas, lorsqu'elle est d\u00e9cid\u00e9e au sein des centres de r\u00e9f\u00e9rence<sup>5<\/sup>.<\/p>\n\n<p>Une biopsie peut sous-estimer le grade de malignit\u00e9 tumorale. Par cons\u00e9quent, lorsque le traitement pr\u00e9op\u00e9ratoire est envisageable, l\u2019imagerie radiologique [y compris le scanner\/TDM \u00e0 \u00e9mission de positrons [<sup>18<\/sup>F]2-fluoro-2-d\u00e9soxy-D-glucose (FDG-PET\/CT)] peut \u00eatre utile, en plus de la pathologie, pour fournir des informations permettant d\u2019estimer le grade de malignit\u00e9<sup>5<\/sup>.<\/p>\n\n<p>L\u2019\u00e9valuation histopathologique et l\u2019immunomarquage de la concentration de \u03b2-cat\u00e9nine sont importants pour le diagnostic des tumeurs desmo\u00efdes<sup>10<\/sup>.<\/p>\n\n<p>Les lignes directrices du DTWG identifient la positivit\u00e9 nucl\u00e9aire de la \u03b2-cat\u00e9nine comme caract\u00e9ristique immunoph\u00e9notypique cl\u00e9 des tumeurs desmo\u00efdes<sup>8<\/sup>.<\/p>\n\n<p>L\u2019immunopositivit\u00e9 nucl\u00e9aire de la \u03b2-cat\u00e9nine a \u00e9t\u00e9 rapport\u00e9e dans 80&nbsp;\u00e0&nbsp;98&nbsp;% des cas de tumeurs desmo\u00efdes sporadiques, et dans 60&nbsp;\u00e0&nbsp;70&nbsp;% des cas de tumeurs desmo\u00efdes associ\u00e9es \u00e0 la polypose ad\u00e9nomateuse familiale (PAF)<sup>8<\/sup>.<\/p> <\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"wf-cell shown\">\n\t\t\t\t\t\t<div class=\"the7-icon-box-grid\">\t\t\t\t\t\t\t<div class=\"box-content-wrapper\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-icon-div\" aria-label=\"Tests g\u00e9n\u00e9tiques\">\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-icon\">\n\t\t\t\t\t\t\t\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"186\" height=\"186\" viewBox=\"0 0 186 186\" fill=\"none\"><g clip-path=\"url(#clip0_316_1046)\"><g clip-path=\"url(#clip1_316_1046)\"><path opacity=\"0.3\" d=\"M173.66 12.22C157.36 -4.08 130.95 -4.08 114.65 12.22C108.36 18.51 104.56 26.3 103.13 34.43C103.09 34.62 103.03 34.75 102.99 34.93C98.6599 57.59 103.65 73.86 75.0599 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129.84L54.2601 142.4\" stroke=\"#005EA7\" stroke-width=\"3.52\" stroke-miterlimit=\"10\"><\/path><path d=\"M87.75 75.4102L108.69 96.3401\" stroke=\"#005EA7\" stroke-width=\"3.52\" stroke-miterlimit=\"10\"><\/path><path d=\"M66.8201 96.3401L87.7501 117.28\" stroke=\"#005EA7\" stroke-width=\"3.52\" stroke-miterlimit=\"10\"><\/path><path d=\"M108.69 16.79C97.3901 28.1 100.43 49.92 112.63 67.65C138.04 104.57 123.09 119.57 116.29 126.43C108.1 134.61 94.1301 135.53 80.3101 130.77\" stroke=\"#005EA7\" stroke-width=\"3.52\" stroke-miterlimit=\"10\"><\/path><\/g><\/g><defs><clipPath id=\"clip0_316_1046\"><rect width=\"186\" height=\"186\" fill=\"white\"><\/rect><\/clipPath><clipPath id=\"clip1_316_1046\"><rect width=\"185.89\" height=\"185.89\" fill=\"white\"><\/rect><\/clipPath><\/defs><\/svg>\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/a>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"box-content\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<h5 class=\"box-heading\">\n\t\t\t\t\t\t\t\t\t\t\t<a aria-label=\"Tests g\u00e9n\u00e9tiques\">\t\t\t\t\t\t\t\t\t\t\t\tTests g\u00e9n\u00e9tiques\t\t\t\t\t\t\t\t\t\t\t<\/a>\t\t\t\t\t\t\t\t\t\t<\/h5>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"box-description\"><p>Les mutations CTNNB1 et les mutations APC s\u2019excluent mutuellement dans les tumeurs desmo\u00efdes. La d\u00e9tection d\u2019une mutation somatique CTNNB1 permet ainsi d\u2019exclure une pathologie syndromique. \u00c0 l\u2019inverse, le statut de type sauvage de la mutation CTNNB1 dans les tumeurs desmo\u00efdes, notamment dans les tumeurs intra-abdominales, doit\nfaire suspecter une PAF et n\u00e9cessite un bilan clinique diagnostique plus approfondi (par&nbsp;exemple, coloscopie ou test de la lign\u00e9e germinale)<sup>8<\/sup>.<\/p>\n\n<p>Par cons\u00e9quent, les <strong>lignes directrices consensuelles du DTWG recommandent d\u2019effectuer une analyse de mutation sur des \u00e9chantillons de biopsie de tumeur desmo\u00efde afin de confirmer le diagnostic et d\u2019orienter les actions, le cas \u00e9ch\u00e9ant<\/strong><sup>8<\/sup>.<\/p>\n<ul>\n<li>85&nbsp;%&nbsp;\u00e0&nbsp;90&nbsp;% des tumeurs desmo\u00efdes sont sporadiques, et le plus souvent associ\u00e9es \u00e0 l\u2019activation de mutation du g\u00e8ne CTNNB1 de la \u03b2-cat\u00e9nine<sup>11<\/sup>.<\/li>\n<li>10 % \u00e0 15 % des tumeurs desmo\u00efdes sont syndromiques dans le contexte de la PAF et associ\u00e9es \u00e0 une inactivation de la lign\u00e9e germinale dans les mutations de l'APC<sup>11<\/sup>.<\/li>\n<\/ul><\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e88e978 elementor-widget elementor-widget-the7_button_widget\" data-id=\"e88e978\" data-element_type=\"widget\" data-widget_type=\"the7_button_widget.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div class=\"elementor-button-wrapper\"><a href=\"https:\/\/www.desmoidtumours.eu\/fr\/prise-en-charge\/\" class=\"box-button elementor-button elementor-size-md\">En savoir plus sur la prise en charge des tumeurs desmo\u00efdes<\/a><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5d1f597 elementor-widget-tablet__width-inherit elementor-widget elementor-widget-text-editor\" data-id=\"5d1f597\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>APC, g\u00e8ne de la polypose ad\u00e9nomateuse coli&nbsp;; TDM, tomodensitom\u00e9trie&nbsp;; CTNNB1, g\u00e8ne de la cat\u00e9nine \u03b21&nbsp;; PAF, polypose ad\u00e9nomateuse familiale&nbsp;; DTWG, Desmoid Tumor Working Group (Groupe de travail sur les tumeurs desmo\u00efdes)&nbsp;; ESMO, European Society for Medical Oncology (Soci\u00e9t\u00e9 europ\u00e9enne d\u2019oncologie m\u00e9dicale)&nbsp;; TEP-FDG, <sup>18<\/sup>tomographie par \u00e9mission de positons fluoro-2-d\u00e9soxy-2-D-glucose\/scanner&nbsp;; GIST, tumeur stromale gastro-intestinale <em>KIT<\/em>, proto-oncog\u00e8ne, oncog\u00e8ne du r\u00e9cepteur tyrosine kinase&nbsp;; IRM, imagerie par r\u00e9sonance magn\u00e9tique&nbsp;; NCCN, National Comprehensive Cancer Network (R\u00e9seau national global de lutte contre le cancer)&nbsp;; SRP, sarcome retrop\u00e9riton\u00e9al&nbsp;; STM, sarcome des tissus mous.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-22d2548 e-con-full e-flex e-con e-parent\" data-id=\"22d2548\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-55f214d e-flex e-con-boxed e-con e-child\" data-id=\"55f214d\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-b6c3370 e-con-full e-flex e-con e-child\" data-id=\"b6c3370\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-17c0cf8 elementor-widget elementor-widget-the7-accordion\" data-id=\"17c0cf8\" data-element_type=\"widget\" data-widget_type=\"the7-accordion.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-accordion the7-adv-accordion\" data-accordion-type=\"accordion\" role=\"tablist\">\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<h5 id=\"elementor-tab-title-2491\" class=\"elementor-tab-title the7-accordion-header deactive-default\" data-tab=\"1\" role=\"tab\" aria-controls=\"elementor-tab-content-2491\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><svg class=\"e-font-icon-svg e-fas-plus\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M416 208H272V64c0-17.67-14.33-32-32-32h-32c-17.67 0-32 14.33-32 32v144H32c-17.67 0-32 14.33-32 32v32c0 17.67 14.33 32 32 32h144v144c0 17.67 14.33 32 32 32h32c17.67 0 32-14.33 32-32V304h144c17.67 0 32-14.33 32-32v-32c0-17.67-14.33-32-32-32z\"><\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><svg class=\"e-font-icon-svg e-fas-minus\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M416 208H32c-17.67 0-32 14.33-32 32v32c0 17.67 14.33 32 32 32h384c17.67 0 32-14.33 32-32v-32c0-17.67-14.33-32-32-32z\"><\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" href=\"\">R\u00e9f\u00e9rences<\/a>\n\t\t\t\t\t<\/h5>\n\t\t\t\t\t<div id=\"elementor-tab-content-2491\" class=\"elementor-tab-content elementor-clearfix deactive-default\" data-tab=\"1\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-2491\"><ol>\n<li>Husson O et al. Desmoid fibromatosis through the patients\u2019 eyes: time to change the focus and organisation of care? <em>Support Care Cancer<\/em>. 2019; 27(3):965-980.<\/li>\n<li>Joglekar SB et al. Current perspectives on desmoid tumors: the Mayo Clinic approach. <em>Cancers<\/em> (<em>Basel<\/em>). 2011;3(3):3143-3155.<\/li>\n<li>Gronchi A et al. Desmoid Tumor Working Group. The management of desmoid tumours: a joint global consensus-based guideline approach for adult and paediatric patients. <em>Eur J Cancer<\/em>. 2020;127:96-107.<\/li>\n<li>Kasper B et al. Desmoid Tumor Working Group. Current management of desmoid tumors: a review. <em>JAMA Oncol<\/em>. 2024;10(8):1121-1128.<\/li>\n<li>Gronchi A et al. ESMO Guidelines Committee, EURACAN and GENTURIS. Soft tissue and visceral sarcomas: ESMO-EURACAN-GENTURIS Clinical Practice Guidelines for diagnosis, treatment and follow-up. <em>Ann Oncol<\/em>. 2021;32(11):1348-1365.<\/li>\n<li>R\u00e9f\u00e9renc\u00e9 avec l\u2019autorisation des lignes directrices en mati\u00e8re de pratique clinique en oncologie du NCCN (lignes directrices du NCCN\u00ae) pour le sarcome des tissus mous V.1.2024. \u00a9 National Comprehensive Cancer Network, Inc. 2024. Tous droits r\u00e9serv\u00e9s. Consult\u00e9 le 29&nbsp;avril&nbsp;2024. Pour consulter la derni\u00e8re version compl\u00e8te des lignes directrices, rendez-vous en ligne sur NCCN.org. Le NCCN n\u2019offre aucune garantie de quelque sorte, que ce soit concernant leur contenu, leur utilisation ou leur application et d\u00e9cline toute responsabilit\u00e9 quant \u00e0 leur quelconque application ou utilisation.<\/li>\n<li>Bektas M et al. Desmoid tumors: a comprehensive review. <em>Adv Ther<\/em>. 2023;40(9):3697-3722.<\/li>\n<li>Kasper B et al. Desmoid tumor working group. Current management of desmoid tumors: a review. [supplementary appendix] <em>JAMA Oncol<\/em>. 2024;10(8):1121-1128.<\/li>\n<li>Smolle MA et al. Diagnosis and treatment of soft-tissue sarcomas of the extremities and trunk. <em>EFORT<\/em><em>Open Rev<\/em>. 2017;2(10):421-431.<\/li>\n<li>Carlson JW et al. Immunohistochemistry for \u03b2-catenin in the differential diagnosis of spindle cell lesions: analysis of a series and review of the literature. <em>Histopathology<\/em>. 2007;51(4):509-514.<\/li>\n<li>Penel N et al. Adult desmoid tumors: biology, management and ongoing trials. <em>Curr Opin Oncol<\/em>. 2017;29(4):268-274.<\/li>\n<\/ol>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Recommandations des lignes directrices Diagnostic diff\u00e9rentiel Strat\u00e9gies de diagnostiques Diagnostic Recommandations des lignes directrices Une collaboration avec des sp\u00e9cialistes peut am\u00e9liorer le pronostic et la qualit\u00e9 de vie des patients1,2 Lignes directrices du DTWG\u2020* \u00ab\u00a0Il est recommand\u00e9 de faire appel \u00e0 des \u00e9quipes pluridisciplinaires exp\u00e9riment\u00e9es au moment du diagnostic initial, pour obtenir les meilleurs conseils&hellip;<\/p>\n","protected":false},"author":9,"featured_media":0,"parent":0,"menu_order":5,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"_acf_changed":true,"footnotes":""},"class_list":["post-21289","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Tumeurs desmo\u00efdes\u00a0: diagnostic | SpringWorks Therapeutics<\/title>\n<meta name=\"description\" content=\"D\u00e9couvrez les strat\u00e9gies en mati\u00e8re de diagnostic et les recommandations fond\u00e9es sur des lignes directrices encourageant la participation d\u2019\u00e9quipes pluridisciplinaires sp\u00e9cialis\u00e9es et exp\u00e9riment\u00e9es dans le domaine des tumeurs desmo\u00efdes.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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