{"id":21939,"date":"2024-08-01T13:48:59","date_gmt":"2024-08-01T13:48:59","guid":{"rendered":"https:\/\/www.desmoidtumours.eu\/diagnosi\/"},"modified":"2026-02-10T10:35:48","modified_gmt":"2026-02-10T10:35:48","slug":"diagnosi","status":"publish","type":"page","link":"https:\/\/www.desmoidtumours.eu\/it\/diagnosi\/","title":{"rendered":"Diagnosi"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"21939\" class=\"elementor elementor-21939 elementor-20166\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9152995 e-flex e-con-boxed e-con e-parent\" data-id=\"9152995\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-de1bdb6 elementor-widget elementor-widget-spacer\" data-id=\"de1bdb6\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-20a8237f the7-e-sticky-row-yes e-flex e-con-boxed e-con e-parent\" data-id=\"20a8237f\" data-element_type=\"container\" id=\"sub-nav-bar\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;the7_sticky_row&quot;:&quot;yes&quot;,&quot;the7_sticky_row_offset&quot;:116,&quot;the7_sticky_row_offset_tablet_extra&quot;:60,&quot;the7_sticky_row_offset_tablet&quot;:50,&quot;the7_sticky_row_offset_mobile&quot;:60,&quot;the7_sticky_row_devices&quot;:[&quot;desktop&quot;,&quot;laptop&quot;,&quot;tablet_extra&quot;,&quot;tablet&quot;,&quot;mobile&quot;]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-17c10cd2 e-con-full e-flex e-con e-child\" data-id=\"17c10cd2\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-305c1c24 elementor-widget elementor-widget-text-editor\" data-id=\"305c1c24\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><a href=\"#guidelines-recommendations\">Raccomandazioni delle linee guida<\/a><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1fa35116 e-con-full e-flex e-con e-child\" data-id=\"1fa35116\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-76ba3586 elementor-widget elementor-widget-text-editor\" data-id=\"76ba3586\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><a href=\"#differential-diagnosis\">Diagnosi differenziale<\/a><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-574ab19d e-con-full e-flex e-con e-child\" data-id=\"574ab19d\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-74fe7b8e elementor-widget elementor-widget-text-editor\" data-id=\"74fe7b8e\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><a href=\"#diagnostic-strategies\">Strategie diagnostiche<\/a><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7ffc003c e-con-full e-flex e-con e-parent\" data-id=\"7ffc003c\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-3707e425 e-flex e-con-boxed e-con e-child\" data-id=\"3707e425\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e0bc626 elementor-widget elementor-widget-heading\" data-id=\"e0bc626\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Diagnosi<\/h1>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-72166f9 e-con-full section e-flex e-con e-parent\" data-id=\"72166f9\" data-element_type=\"container\" id=\"guidelines-recommendations\">\n\t\t<div class=\"elementor-element elementor-element-fad0ebe e-flex e-con-boxed e-con e-child\" data-id=\"fad0ebe\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-f749dd1 e-con-full e-flex e-con e-child\" data-id=\"f749dd1\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-dd5ee8e e-con-full e-flex e-con e-child\" data-id=\"dd5ee8e\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3307b47 elementor-widget-tablet__width-inherit elementor-widget elementor-widget-the7-heading\" data-id=\"3307b47\" data-element_type=\"widget\" data-widget_type=\"the7-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"the7-heading-title elementor-size-default\">Raccomandazioni delle linee guida<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0b99779 elementor-widget-tablet__width-inherit elementor-widget elementor-widget-the7-heading\" data-id=\"0b99779\" data-element_type=\"widget\" data-widget_type=\"the7-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"the7-heading-title elementor-size-default\">Collaborare con gli specialisti pu\u00f2 migliorare la prognosi e la qualit\u00e0 della vita dei pazienti<sup>1,2<\/sup><\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-204ba23 e-con-full e-flex e-con e-child\" data-id=\"204ba23\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-62a4669 elementor-widget-tablet__width-inherit elementor-widget elementor-widget-the7-heading\" data-id=\"62a4669\" data-element_type=\"widget\" data-widget_type=\"the7-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h5 class=\"the7-heading-title elementor-size-default\">Linee guida DTWG<sup>\u2020*<\/sup><\/h5>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-efd3815 elementor-widget-tablet__width-inherit elementor-widget elementor-widget-text-editor\" data-id=\"efd3815\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><em><strong>\u201cAl momento della diagnosi iniziale, si consiglia di inviare il paziente a team multidisciplinari esperti, per ottenere una consulenza ottimale sulla sicurezza di una strategia di osservazione iniziale.<sup>3<\/sup>\u201d<\/strong><\/em><\/p><p><em><b>\u201cLa gestione dei tumori desmoidi \u00e8 complessa e<\/b><br \/><b>deve essere eseguita esclusivamente in centri di riferimento autorizzati alla gestione dei\u00a0i tumori desmoidi, dotati di un comitato oncologico multidisciplinare.<\/b><sup style=\"font-weight: bold;\">*4<\/sup><b>\u201d<\/b><\/em><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0f4f410 elementor-widget-tablet__width-inherit elementor-widget elementor-widget-text-editor\" data-id=\"0f4f410\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><sup>\u2020<\/sup>Il Gruppo di lavoro sui tumori desmoidi (Desmoid Tumour Working Group, DTWG) include oltre 50 esperti di sarcoma provenienti da diverse discipline, oltre a pazienti e portavoce dei pazienti provenienti da Europa, Nord America e Giappone.<sup>3<\/sup><br \/><sup>*<\/sup>Per aggiornare le linee guida di consenso basate sull\u2019evidenza globale 2020 sulla gestione dei pazienti con tumore desmoide, il Gruppo di lavoro sui tumori desmoidi ha convocato un incontro nel 2023 raggiungendo un consenso sugli aspetti chiave della gestione dei pazienti con questi tipi di tumori.<sup>4<\/sup><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-e412980 e-con-full e-flex e-con e-child\" data-id=\"e412980\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5a53d16 elementor-widget-tablet__width-inherit elementor-widget elementor-widget-the7-heading\" data-id=\"5a53d16\" data-element_type=\"widget\" data-widget_type=\"the7-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h5 class=\"the7-heading-title elementor-size-default\">Sarcomi dei tessuti molli e viscerali ESMO: Linee guida per la pratica clinica dell'ESMO-EURACAN-GENTURIS<\/h5>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d41feed elementor-widget-tablet__width-inherit elementor-widget elementor-widget-text-editor\" data-id=\"d41feed\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><em><b>\u201cLa diagnosi patologica deve essere effettuata da un anatomopatologo\u00a0esperto di sarcoma.<\/b><sup style=\"font-weight: bold;\">5<\/sup><b>\u201d<\/b><\/em><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3a1e296 e-con-full e-flex e-con e-child\" data-id=\"3a1e296\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-cb36f04 elementor-widget-tablet__width-inherit elementor-widget elementor-widget-the7-heading\" data-id=\"cb36f04\" data-element_type=\"widget\" data-widget_type=\"the7-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h5 class=\"the7-heading-title elementor-size-default\">Linee guida NCCN<\/h5>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-27c54fa elementor-widget-tablet__width-inherit elementor-widget elementor-widget-text-editor\" data-id=\"27c54fa\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><em><strong>\u201cPrima dell\u2019avvio del piano di trattamento, tutti i pazienti devono essere valutati e trattati da un team multidisciplinare con competenze ed esperienza nell\u2019ambito dei tumori desmoidi.<sup>6<\/sup>\u201d<\/strong><\/em><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7464f97 e-con-full section e-flex e-con e-parent\" data-id=\"7464f97\" data-element_type=\"container\" id=\"differential-diagnosis\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-9f6bea4 e-flex e-con-boxed e-con e-child\" data-id=\"9f6bea4\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-17e311b e-con-full e-flex e-con e-child\" data-id=\"17e311b\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-a2a6bca e-con-full e-flex e-con e-child\" data-id=\"a2a6bca\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-48f98a4 elementor-widget-tablet__width-inherit elementor-widget elementor-widget-the7-heading\" data-id=\"48f98a4\" data-element_type=\"widget\" data-widget_type=\"the7-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"the7-heading-title elementor-size-default\">Diagnosi differenziale<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a4c153f elementor-widget-tablet__width-inherit elementor-widget elementor-widget-the7-heading\" data-id=\"a4c153f\" data-element_type=\"widget\" data-widget_type=\"the7-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"the7-heading-title elementor-size-default\">Il raggiungimento di una diagnosi tempestiva e accurata rimane una sfida<sup>7<\/sup><\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b2027ab elementor-widget-tablet__width-inherit bullet-custom elementor-widget elementor-widget-text-editor\" data-id=\"b2027ab\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>La diagnosi errata \u00e8 comune nelle malattie rare come i tumori desmoidi.<sup>7<\/sup><\/p><ul><li>Il <strong>30-40%<\/strong> dei casi di tumore desmoide \u00e8 stato segnalato come erroneamente diagnosticato in seguito ad analisi istologica<sup>7<\/sup><\/li><li>La diagnosi differenziale \u00e8 ampia e include proliferazioni fibroblastiche\/miofibroblastiche sia benigne che maligne, tra cui:<sup>8<\/sup><ul><li>Cicatrici ipertrofiche<\/li><li>Cheloidi e fascite nodulare<\/li><li>Sarcoma fibromixoide di basso grado<\/li><li>Sarcoma miofibroblastico di basso grado<\/li><\/ul><\/li><li>Nella diagnosi differenziale possono rientrare anche i tumori delle guaine nervose come schwannoma, neurofibroma, perineurioma e tumori della muscolatura liscia come i leiomiomi<sup>8<\/sup><\/li><li>Il sarcoma fibromixoide di basso grado rappresenta la diagnosi differenziale pi\u00f9 difficile, in quanto pu\u00f2 mostrare una significativa sovrapposizione morfologica con i tumori desmoidi<sup>8<\/sup><\/li><li>Un\u2019altra importante diagnosi differenziale relativa ai tumori desmoidi intra\u2013addominali \u00e8 il tumore stromale gastrointestinale (gastrointestinal stromal tumour, GIST), in quanto alcuni casi di tumori desmoidi possono presentare un&#8217;espressione debole e focalizzata di <em>KIT<\/em><sup> 8<\/sup><\/li><\/ul><p>Una diagnosi accurata rimane fondamentale per pianificare il trattamento in modo appropriato.<sup>8<\/sup><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-5a6bdef e-con-full section e-flex e-con e-parent\" data-id=\"5a6bdef\" data-element_type=\"container\" id=\"diagnostic-strategies\">\n\t\t<div class=\"elementor-element elementor-element-db3c6a3 e-flex e-con-boxed e-con e-child\" data-id=\"db3c6a3\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-0cb45ca e-con-full e-flex e-con e-child\" data-id=\"0cb45ca\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-0c069ba elementor-widget-tablet__width-inherit elementor-widget elementor-widget-the7-heading\" data-id=\"0c069ba\" data-element_type=\"widget\" data-widget_type=\"the7-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"the7-heading-title elementor-size-default\">Strategie diagnostiche<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-06a8980 elementor-widget-tablet__width-inherit elementor-widget elementor-widget-the7-heading\" data-id=\"06a8980\" data-element_type=\"widget\" data-widget_type=\"the7-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"the7-heading-title elementor-size-default\">La diagnosi richiede la revisione dell\u2019anamnesi medica e l\u2019esame obiettivo, la diagnostica per immagini e la biopsia, nonch\u00e9 la valutazione istopatologica<sup>7<\/sup><\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-41c7149 elementor-widget-tablet__width-inherit elementor-widget elementor-widget-text-editor\" data-id=\"41c7149\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>La diagnosi di tumori desmoidi deve essere confermata da un patologo esperto di tessuti molli.<sup>8<\/sup><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a4694fc no-link bullet-custom content-align-left icon-box-vertical-align-top icon-position-left icon-vertical-align-start elementor-widget elementor-widget-the7_icon_box_grid_widget\" data-id=\"a4694fc\" data-element_type=\"widget\" data-widget_type=\"the7_icon_box_grid_widget.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div class=\"the7-box-grid-wrapper the7-elementor-widget loading-effect-none the7_icon_box_grid_widget-a4694fc\">\t\t\t<div class=\"dt-css-grid\">\n\t\t\t\t\t\t\t\t\t<div class=\"wf-cell shown\">\n\t\t\t\t\t\t<div class=\"the7-icon-box-grid\">\t\t\t\t\t\t\t<div class=\"box-content-wrapper\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-icon-div\" aria-label=\"Diagnostica per immagini\">\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-icon\">\n\t\t\t\t\t\t\t\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"186\" height=\"186\" viewBox=\"0 0 186 186\" fill=\"none\"><g clip-path=\"url(#clip0_316_1048)\"><g clip-path=\"url(#clip1_316_1048)\"><path opacity=\"0.3\" d=\"M173.66 12.22C157.36 -4.08 130.95 -4.08 114.65 12.22C108.36 18.51 104.56 26.3 103.13 34.43C103.09 34.62 103.03 34.75 102.99 34.93C98.6599 57.59 103.65 73.86 75.0599 102.46C46.4599 131.05 42.7899 123.43 19.2599 131.29L19.3399 131.38C15.2799 132.7 11.4299 134.86 8.19994 138.08C-2.73006 149.02 -2.73006 166.74 8.19994 177.67C19.1399 188.61 36.8599 188.61 47.7899 177.67C51.0199 174.44 53.1799 170.59 54.4999 166.53L54.5899 166.61C62.4499 143.07 54.8299 139.41 83.4199 110.81C112.01 82.21 128.29 87.2 150.95 82.88C151.14 82.85 151.26 82.78 151.44 82.74C159.58 81.31 167.38 77.5 173.66 71.21C189.96 54.92 189.96 28.5 173.66 12.2\" fill=\"#05C0DA\"><\/path><path d=\"M109.84 137.97C125.28 137.97 137.8 117.81 137.8 92.9501C137.8 68.08 125.28 47.9301 109.84 47.9301C97.33 47.9301 86.74 61.1601 83.17 79.4001\" fill=\"white\"><\/path><path d=\"M109.84 47.92H136.41C151.85 47.92 164.37 68.08 164.37 92.94C164.37 117.81 151.85 137.96 136.41 137.96H109.84H86.0601\" fill=\"white\"><\/path><path d=\"M126.24 101.09H27.8501C25.0701 101.09 22.8201 103.34 22.8201 106.12C22.8201 108.9 25.0701 111.15 27.8501 111.15H80.4501H112.8\" fill=\"white\"><\/path><path d=\"M101.2 90.51C94.0901 89.13 89.9701 83.04 72.5501 85.82C67.1001 86.69 62.8601 92.94 39.1401 92.94C34.0701 92.94 34.0201 97.53 34.0701 100.62\" fill=\"white\"><\/path><path d=\"M91.22 93.6901H77.52C75.32 93.8701 74.03 94.5801 73.87 96.5901C73.71 98.6001 75.11 100.92 76.99 101.09H97\" fill=\"white\"><\/path><path d=\"M110.11 101.09C114.55 101.09 118.15 97.58 118.15 93.24C118.15 88.91 114.4 86.53 110.11 85.4C103.82 83.74 100.56 85.9 100.56 95.33\" fill=\"white\"><\/path><path d=\"M46.22 129.03C43.83 129.03 41.89 127.03 41.89 124.56C41.89 122.09 43.83 120.09 46.22 120.09H86.06C88.45 120.09 90.39 122.09 90.39 124.56C90.39 127.03 88.45 129.03 86.06 129.03H46.22Z\" fill=\"white\"><\/path><path d=\"M46.22 137.97C43.83 137.97 41.89 135.97 41.89 133.5C41.89 131.03 43.83 129.03 46.22 129.03H86.06C88.45 129.03 90.39 131.03 90.39 133.5C90.39 135.97 88.45 137.97 86.06 137.97H46.22Z\" fill=\"white\"><\/path><path d=\"M46.22 120.1C43.83 120.1 41.89 118.1 41.89 115.63C41.89 113.16 43.83 111.16 46.22 111.16H86.06C88.45 111.16 90.39 113.16 90.39 115.63C90.39 118.1 88.45 120.1 86.06 120.1H46.22Z\" fill=\"white\"><\/path><path d=\"M99.21 118.44C102.11 123.09 105.82 125.88 109.88 125.88C119.21 125.88 126.77 111.13 126.77 92.94C126.77 74.75 119.21 60 109.88 60C102.67 60 96.51 68.82 94.09 81.23\" fill=\"white\"><\/path><path d=\"M109.84 137.97C125.28 137.97 137.8 117.81 137.8 92.9501C137.8 68.08 125.28 47.9301 109.84 47.9301C97.33 47.9301 86.74 61.1601 83.17 79.4001\" stroke=\"#005EA7\" stroke-width=\"3.52\" stroke-miterlimit=\"10\"><\/path><path d=\"M109.84 47.92H136.41C151.85 47.92 164.37 68.08 164.37 92.94C164.37 117.81 151.85 137.96 136.41 137.96H109.84H86.0601\" stroke=\"#005EA7\" stroke-width=\"3.52\" stroke-miterlimit=\"10\"><\/path><path d=\"M126.24 101.09H27.8501C25.0701 101.09 22.8201 103.34 22.8201 106.12C22.8201 108.9 25.0701 111.15 27.8501 111.15H80.4501H112.8\" stroke=\"#005EA7\" stroke-width=\"3.52\" stroke-miterlimit=\"10\"><\/path><path d=\"M21.52 137.97H58.78\" stroke=\"#005EA7\" stroke-width=\"3.52\" stroke-miterlimit=\"10\"><\/path><path d=\"M101.2 90.51C94.0901 89.13 89.9701 83.04 72.5501 85.82C67.1001 86.69 62.8601 92.94 39.1401 92.94C34.0701 92.94 34.0201 97.53 34.0701 100.62\" stroke=\"#005EA7\" stroke-width=\"3.52\" stroke-miterlimit=\"10\"><\/path><path d=\"M91.22 93.6901H77.52C75.32 93.8701 74.03 94.5801 73.87 96.5901C73.71 98.6001 75.11 100.92 76.99 101.09H97\" stroke=\"#005EA7\" stroke-width=\"3.52\" stroke-miterlimit=\"10\"><\/path><path d=\"M110.11 101.09C114.55 101.09 118.15 97.58 118.15 93.24C118.15 88.91 114.4 86.53 110.11 85.4C103.82 83.74 100.56 85.9 100.56 95.33\" stroke=\"#005EA7\" stroke-width=\"3.52\" stroke-miterlimit=\"10\"><\/path><path d=\"M46.22 129.03C43.83 129.03 41.89 127.03 41.89 124.56C41.89 122.09 43.83 120.09 46.22 120.09H86.06C88.45 120.09 90.39 122.09 90.39 124.56C90.39 127.03 88.45 129.03 86.06 129.03H46.22Z\" stroke=\"#005EA7\" stroke-width=\"3.52\" stroke-miterlimit=\"10\"><\/path><path d=\"M46.22 137.97C43.83 137.97 41.89 135.97 41.89 133.5C41.89 131.03 43.83 129.03 46.22 129.03H86.06C88.45 129.03 90.39 131.03 90.39 133.5C90.39 135.97 88.45 137.97 86.06 137.97H46.22Z\" stroke=\"#005EA7\" stroke-width=\"3.52\" stroke-miterlimit=\"10\"><\/path><path d=\"M46.22 120.1C43.83 120.1 41.89 118.1 41.89 115.63C41.89 113.16 43.83 111.16 46.22 111.16H86.06C88.45 111.16 90.39 113.16 90.39 115.63C90.39 118.1 88.45 120.1 86.06 120.1H46.22Z\" stroke=\"#005EA7\" stroke-width=\"3.52\" stroke-miterlimit=\"10\"><\/path><path d=\"M99.21 118.44C102.11 123.09 105.82 125.88 109.88 125.88C119.21 125.88 126.77 111.13 126.77 92.94C126.77 74.75 119.21 60 109.88 60C102.67 60 96.51 68.82 94.09 81.23\" stroke=\"#005EA7\" stroke-width=\"3.52\" stroke-miterlimit=\"10\"><\/path><\/g><\/g><defs><clipPath id=\"clip0_316_1048\"><rect width=\"186\" height=\"186\" fill=\"white\"><\/rect><\/clipPath><clipPath id=\"clip1_316_1048\"><rect width=\"185.89\" height=\"185.89\" fill=\"white\"><\/rect><\/clipPath><\/defs><\/svg>\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/a>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"box-content\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<h5 class=\"box-heading\">\n\t\t\t\t\t\t\t\t\t\t\t<a aria-label=\"Diagnostica per immagini\">\t\t\t\t\t\t\t\t\t\t\t\tDiagnostica per immagini\t\t\t\t\t\t\t\t\t\t\t<\/a>\t\t\t\t\t\t\t\t\t\t<\/h5>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"box-description\"><p>L\u2019ecografia pu\u00f2 essere utilizzata come diagnostica per immagini di prima linea, ma in caso di sospetto di sarcoma dei tessuti molli deve essere seguita da tomografia computerizzata (TC) o risonanza magnetica per immagini (RM).<sup>5<\/sup><\/p>\n\n<p>Nei tumori primari dei tessuti molli la RM \u00e8 la principale modalit\u00e0 di diagnostica per immagini delle estremit\u00e0, della pelvi e del tronco.<sup>5<\/sup><\/p>\n\n<p>Le radiografie standard possono essere utili per escludere un tumore osseo, per rilevare l\u2019erosione ossea con un rischio di frattura e per mostrare calcificazioni.<sup>5<\/sup><\/p>\n\n<p>La TC pu\u00f2 escludere una miosite ossificante nelle lesioni calcificate e ha un ruolo nei sarcomi pleuropolmonari e nei sarcomi retroperitoneali perch\u00e9 in questi casi offre prestazioni sono identiche alla RM.<sup>5<\/sup><\/p> \n\n<p>Le caratteristiche indicative di alto rischio devono richiedere la verifica mediante biopsia:<sup>9<\/sup><\/p>\n<ul>\n<li>Recente aumento delle dimensioni<\/li>\n<li>Posizione profonda rispetto alla fascia<\/li>\n<li>Dimensioni >4 cm<\/li>\n<li>Modelli di crescita invasiva osservati con la diagnostica per immagini<\/li>\n<\/ul>\n<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"wf-cell shown\">\n\t\t\t\t\t\t<div class=\"the7-icon-box-grid\">\t\t\t\t\t\t\t<div class=\"box-content-wrapper\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-icon-div\" aria-label=\"Biopsia con ago a scatto e colorazione per \u03b2-catenina nucleare\">\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-icon\">\n\t\t\t\t\t\t\t\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"186\" height=\"186\" viewBox=\"0 0 186 186\" fill=\"none\"><g clip-path=\"url(#clip0_316_1047)\"><g clip-path=\"url(#clip1_316_1047)\"><path opacity=\"0.3\" d=\"M173.66 12.22C157.36 -4.08 130.95 -4.08 114.65 12.22C108.36 18.51 104.56 26.3 103.13 34.43C103.09 34.62 103.03 34.75 102.99 34.93C98.6599 57.59 103.65 73.86 75.0599 102.46C46.4599 131.05 42.7899 123.43 19.2599 131.29L19.3399 131.38C15.2799 132.7 11.4299 134.86 8.19994 138.08C-2.73006 149.02 -2.73006 166.74 8.19994 177.67C19.1399 188.61 36.8599 188.61 47.7899 177.67C51.0199 174.44 53.1799 170.59 54.4999 166.53L54.5899 166.61C62.4499 143.07 54.8299 139.41 83.4199 110.81C112.01 82.21 128.29 87.2 150.95 82.88C151.14 82.85 151.26 82.78 151.44 82.74C159.58 81.31 167.38 77.5 173.66 71.21C189.96 54.92 189.96 28.5 173.66 12.2\" fill=\"#05C0DA\"><\/path><path d=\"M147.796 55.8709L130.027 38.1013L100.484 67.6442L118.253 85.4138L147.796 55.8709Z\" fill=\"white\" stroke=\"#005EA7\" stroke-width=\"3.52\" stroke-miterlimit=\"10\"><\/path><path d=\"M114.214 81.3812L104.52 71.6868L94.8251 81.3812L104.52 91.0756L114.214 81.3812Z\" fill=\"white\" stroke=\"#005EA7\" stroke-width=\"3.52\" stroke-miterlimit=\"10\"><\/path><path d=\"M99.67 86.22L25.98 159.91\" stroke=\"#005EA7\" stroke-width=\"3.52\" stroke-miterlimit=\"10\"><\/path><path d=\"M109.17 58.96L103.01 52.8C98.78 48.57 98.78 41.71 103.01 37.48C107.24 33.25 114.1 33.25 118.34 37.48L124.5 43.64\" stroke=\"#005EA7\" stroke-width=\"3.52\" stroke-miterlimit=\"10\"><\/path><path d=\"M142.26 61.4L148.42 67.56C152.65 71.79 152.65 78.65 148.42 82.89C144.19 87.12 137.33 87.12 133.09 82.89L126.93 76.73\" stroke=\"#005EA7\" stroke-width=\"3.52\" stroke-miterlimit=\"10\"><\/path><path d=\"M155.889 39.6908L146.195 29.9963L134.061 42.1303L143.755 51.8247L155.889 39.6908Z\" fill=\"white\" stroke=\"#005EA7\" stroke-width=\"3.52\" stroke-miterlimit=\"10\"><\/path><path d=\"M165.91 49.71L136.18 19.98\" stroke=\"#005EA7\" stroke-width=\"3.52\" stroke-miterlimit=\"10\"><\/path><\/g><\/g><defs><clipPath id=\"clip0_316_1047\"><rect width=\"186\" height=\"186\" fill=\"white\"><\/rect><\/clipPath><clipPath id=\"clip1_316_1047\"><rect width=\"185.89\" height=\"185.89\" fill=\"white\"><\/rect><\/clipPath><\/defs><\/svg>\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/a>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"box-content\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<h5 class=\"box-heading\">\n\t\t\t\t\t\t\t\t\t\t\t<a aria-label=\"Biopsia con ago a scatto e colorazione per \u03b2-catenina nucleare\">\t\t\t\t\t\t\t\t\t\t\t\tBiopsia con ago a scatto e colorazione per \u03b2-catenina nucleare\t\t\t\t\t\t\t\t\t\t\t<\/a>\t\t\t\t\t\t\t\t\t\t<\/h5>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"box-description\"><p>Dopo un\u2019adeguata valutazione mediante diagnostica per immagini, l\u2019approccio standard alla diagnosi consiste in biopsie con ago a scatto, possibilmente eseguite con aghi \u226514-16 G.<sup>5<\/sup><\/p>\n\n<p>Una biopsia escissionale pu\u00f2 essere l\u2019opzione pi\u00f9 pratica per lesioni superficiali,< 3 cm. Una biopsia in aperto puo' essere un'altra opzione in casi selezionati quando richiesta nell'ambito di centri di riferimento.<sup>5<\/sup><\/p>\n\n<p>Una biopsia potrebbe sottostimare il grado di malignit\u00e0 del tumore. Pertanto, quando il trattamento preoperatorio rappresenta un\u2019opzione, la diagnostica per immagini radiologica [compresa la tomografia a emissione di positroni\/TC [<sup>18<\/sup>F]2-fluoro-2-deossi-D-glucosio (FDG-PET\/TC)] pu\u00f2 essere utile, oltre all'esame istologico, per fornire informazioni che aiutino a stimare il grado di malignit\u00e0.<sup>5<\/sup><\/p>\n\n<p>La valutazione istopatologica e l\u2019immunocolorazione per la \u03b2-catenina sono importanti per la diagnosi dei tumori desmoidi.<sup>10<\/sup><\/p>\n\n<p>Le linee guida del DTWG identificano la positivit\u00e0 nucleare per la \u03b2-catenina come caratteristica immunofenotipica chiave dei tumori desmoidi.<sup>8<\/sup><\/p>\n\n<p>La presenza di immunopositivit\u00e0 nucleare per la \u03b2-catenina \u00e8 stata segnalata nell'80-98% dei casi di tumore desmoide sporadico e nel 60%-70% dei casi di tumore desmoide familiare adenomatoso (familial adenomatous polyposis, FAP).<sup>8<\/sup><\/p> <\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"wf-cell shown\">\n\t\t\t\t\t\t<div class=\"the7-icon-box-grid\">\t\t\t\t\t\t\t<div class=\"box-content-wrapper\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-icon-div\" aria-label=\"Test genetici\">\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-icon\">\n\t\t\t\t\t\t\t\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"186\" height=\"186\" viewBox=\"0 0 186 186\" fill=\"none\"><g clip-path=\"url(#clip0_316_1046)\"><g clip-path=\"url(#clip1_316_1046)\"><path opacity=\"0.3\" d=\"M173.66 12.22C157.36 -4.08 130.95 -4.08 114.65 12.22C108.36 18.51 104.56 26.3 103.13 34.43C103.09 34.62 103.03 34.75 102.99 34.93C98.6599 57.59 103.65 73.86 75.0599 102.46C46.4599 131.05 42.7899 123.43 19.2599 131.29L19.3399 131.38C15.2799 132.7 11.4299 134.86 8.19994 138.08C-2.73006 149.02 -2.73006 166.74 8.19994 177.67C19.1399 188.61 36.8599 188.61 47.7899 177.67C51.0199 174.44 53.1799 170.59 54.4999 166.53L54.5899 166.61C62.4499 143.07 54.8299 139.41 83.4199 110.81C112.01 82.21 128.29 87.2 150.95 82.88C151.14 82.85 151.26 82.78 151.44 82.74C159.58 81.31 167.38 77.5 173.66 71.21C189.96 54.92 189.96 28.5 173.66 12.2\" fill=\"#05C0DA\"><\/path><path d=\"M43.79 115.19C33.61 110.83 21.72 115.19 13.92 123Z\" fill=\"white\"><\/path><path d=\"M131.72 77.5C155.72 86.87 167.31 75.41 167.31 75.41Z\" fill=\"white\"><\/path><path d=\"M59.8001 168.88C71.1001 157.57 75.0801 142.77 62.8801 125.04C37.4701 88.12 52.4201 73.12 59.2201 66.26C67.4101 58.08 81.3801 57.16 95.2001 61.92\" fill=\"white\"><\/path><path d=\"M108.69 16.79C97.3901 28.1 100.43 49.92 112.63 67.65C138.04 104.57 123.09 119.57 116.29 126.43C108.1 134.61 94.1301 135.53 80.3101 130.77\" fill=\"white\"><\/path><path d=\"M43.79 115.19C33.61 110.83 21.72 115.19 13.92 123\" stroke=\"#005EA7\" stroke-width=\"3.52\" stroke-miterlimit=\"10\"><\/path><path d=\"M131.72 77.5C155.72 86.87 167.31 75.41 167.31 75.41\" stroke=\"#005EA7\" stroke-width=\"3.52\" stroke-miterlimit=\"10\"><\/path><path d=\"M59.8001 168.88C71.1001 157.57 75.0801 142.77 62.8801 125.04C37.4701 88.12 52.4201 73.12 59.2201 66.26C67.4101 58.08 81.3801 57.16 95.2001 61.92\" stroke=\"#005EA7\" stroke-width=\"3.52\" stroke-miterlimit=\"10\"><\/path><path d=\"M71 79.6001L104.5 113.09\" stroke=\"#005EA7\" stroke-width=\"3.52\" stroke-miterlimit=\"10\"><\/path><path d=\"M121.25 29.3501L154.75 62.8501\" stroke=\"#005EA7\" stroke-width=\"3.52\" stroke-miterlimit=\"10\"><\/path><path d=\"M121.25 50.29L133.81 62.85\" stroke=\"#005EA7\" stroke-width=\"3.52\" stroke-miterlimit=\"10\"><\/path><path d=\"M23.76 132.84L52.26 161.34\" stroke=\"#005EA7\" stroke-width=\"3.52\" stroke-miterlimit=\"10\"><\/path><path d=\"M41.6901 129.84L54.2601 142.4\" stroke=\"#005EA7\" stroke-width=\"3.52\" stroke-miterlimit=\"10\"><\/path><path d=\"M87.75 75.4102L108.69 96.3401\" stroke=\"#005EA7\" stroke-width=\"3.52\" stroke-miterlimit=\"10\"><\/path><path d=\"M66.8201 96.3401L87.7501 117.28\" stroke=\"#005EA7\" stroke-width=\"3.52\" stroke-miterlimit=\"10\"><\/path><path d=\"M108.69 16.79C97.3901 28.1 100.43 49.92 112.63 67.65C138.04 104.57 123.09 119.57 116.29 126.43C108.1 134.61 94.1301 135.53 80.3101 130.77\" stroke=\"#005EA7\" stroke-width=\"3.52\" stroke-miterlimit=\"10\"><\/path><\/g><\/g><defs><clipPath id=\"clip0_316_1046\"><rect width=\"186\" height=\"186\" fill=\"white\"><\/rect><\/clipPath><clipPath id=\"clip1_316_1046\"><rect width=\"185.89\" height=\"185.89\" fill=\"white\"><\/rect><\/clipPath><\/defs><\/svg>\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/a>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"box-content\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<h5 class=\"box-heading\">\n\t\t\t\t\t\t\t\t\t\t\t<a aria-label=\"Test genetici\">\t\t\t\t\t\t\t\t\t\t\t\tTest genetici\t\t\t\t\t\t\t\t\t\t\t<\/a>\t\t\t\t\t\t\t\t\t\t<\/h5>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"box-description\"><p>Le mutazioni di CTNNB1 e le mutazioni di APC si escludono a vicenda nei tumori desmoidi, pertanto l'identificazione di una mutazione somatica di CTNNB1 pu\u00f2 aiutare a escludere una condizione sindromica. Al contrario, lo stato CTNNB1 wild-type nei tumori desmoidi, specialmente in un tumore intra-addominale, deve\nfar sospettare una FAP e richiedere un esame clinico diagnostico pi\u00f9 approfondito (per es., colonscopia o test della linea germinale).<sup>8<\/sup><\/p>\n\n<p>Pertanto, le <strong>linee guida di consenso del DTWG raccomandano di eseguire un\u2019analisi mutazionale in campioni bioptici di tumore desmoide per confermare la diagnosi e guidare l'iter diagnostico, ove appropriato<\/strong>.<sup>8<\/sup><\/p>\n<ul>\n<li>L\u201985%-90% dei tumori desmoidi \u00e8 sporadico e il pi\u00f9 delle volte \u00e8 associato a mutazioni attivanti del gene della \u03b2-catenina CTNNB1<sup>11<\/sup><\/li>\n<li>Il 10%-15% dei tumori desmoidi \u00e8 sindromico nel contesto della FAP e associato a mutazioni inattivanti della linea germinale del gene <i>APC<\/i><sup>11<\/sup><\/li>\n<\/ul><\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e88e978 elementor-widget elementor-widget-the7_button_widget\" data-id=\"e88e978\" data-element_type=\"widget\" data-widget_type=\"the7_button_widget.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div class=\"elementor-button-wrapper\"><a href=\"https:\/\/www.desmoidtumours.eu\/it\/gestione\/\" class=\"box-button elementor-button elementor-size-md\">Maggiori informazioni sulla gestione dei tumori desmoidi<\/a><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5d1f597 elementor-widget-tablet__width-inherit elementor-widget elementor-widget-text-editor\" data-id=\"5d1f597\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>APC, Gene responsabile della poliposi adenomatosa; TC, Tomografia computerizzata; CTNNB1, gene della \u03b21-catenina; FAP, Poliposi adenomatosa familiare; DTWG Desmoid Tumor Working Group; ESMO European Society for Medical Oncology; FDG-PET\/TC, tomografia a emissione di positroni\/TC <sup>con 18<\/sup>F-2-Fluoro-2-Deoxy-D-Glucose; GIST, Tumore stromale gastrointestinale; <em>KIT<\/em>, proto-oncogene, oncogene recettore tirosin-chinasico; RM, Risonanza magnetica per immagini; NCCN, National Comprehensive Cancer Network; RPS, Sarcoma retroperitoneale; STS, Sarcoma dei tessuti molli.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-22d2548 e-con-full e-flex e-con e-parent\" data-id=\"22d2548\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-55f214d e-flex e-con-boxed e-con e-child\" data-id=\"55f214d\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-b6c3370 e-con-full e-flex e-con e-child\" data-id=\"b6c3370\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-17c0cf8 elementor-widget elementor-widget-the7-accordion\" data-id=\"17c0cf8\" data-element_type=\"widget\" data-widget_type=\"the7-accordion.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-accordion the7-adv-accordion\" data-accordion-type=\"accordion\" role=\"tablist\">\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<h5 id=\"elementor-tab-title-2491\" class=\"elementor-tab-title the7-accordion-header deactive-default\" data-tab=\"1\" role=\"tab\" aria-controls=\"elementor-tab-content-2491\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><svg class=\"e-font-icon-svg e-fas-plus\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M416 208H272V64c0-17.67-14.33-32-32-32h-32c-17.67 0-32 14.33-32 32v144H32c-17.67 0-32 14.33-32 32v32c0 17.67 14.33 32 32 32h144v144c0 17.67 14.33 32 32 32h32c17.67 0 32-14.33 32-32V304h144c17.67 0 32-14.33 32-32v-32c0-17.67-14.33-32-32-32z\"><\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><svg class=\"e-font-icon-svg e-fas-minus\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M416 208H32c-17.67 0-32 14.33-32 32v32c0 17.67 14.33 32 32 32h384c17.67 0 32-14.33 32-32v-32c0-17.67-14.33-32-32-32z\"><\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" href=\"\">Riferimenti<\/a>\n\t\t\t\t\t<\/h5>\n\t\t\t\t\t<div id=\"elementor-tab-content-2491\" class=\"elementor-tab-content elementor-clearfix deactive-default\" data-tab=\"1\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-2491\"><ol>\n<li>Husson O et al. Desmoid fibromatosis through the patients\u2019 eyes: time to change the focus and organisation of care? <em>Support Care Cancer<\/em>. 2019;27(3):965-980.<\/li>\n<li>Joglekar SB et al. Current perspectives on desmoid tumors: the Mayo Clinic approach. <em>Cancers<\/em> (<em>Basel<\/em>). 2011;3(3):3143-3155.<\/li>\n<li>Gronchi A et al. Desmoid Tumor Working Group. The management of desmoid tumours: a joint global consensus-based guideline approach for adult and paediatric patients. <em>Eur J Cancer<\/em>. 2020; 127: 96-107.<\/li>\n<li>Kasper B et al. Desmoid Tumor Working Group. Current management of desmoid tumors: a review. <em>JAMA Oncol<\/em>. 2024; 10(8):1121-1128.<\/li>\n<li>Gronchi A et al. ESMO Guidelines Committee, EURACAN and GENTURIS. Soft tissue and visceral sarcomas: ESMO-EURACAN-GENTURIS Clinical Practice Guidelines for diagnosis, treatment and follow-up. <em>Ann Oncol<\/em>. 2021;32(11):1348-1365.<\/li>\n<li>Citato con l\u2019autorizzazione delle NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines\u00ae) per il sarcoma dei tessuti molli V.1.2024. \u00a9 National Comprehensive Cancer Network, Inc. 2024. Tutti i diritti riservati. Accesso 29 aprile 2024. Per visualizzare la versione pi\u00f9 recente e completa delle linee guida, visita il sito NCCN.org. NCCN non fornisce alcuna garanzia di alcun tipo in merito al loro contenuto, utilizzo o applicazione e declina qualsiasi responsabilit\u00e0 per la loro applicazione o il loro utilizzo in qualsiasi modo.<\/li>\n<li>Bektas M et al. Desmoid tumors: a comprehensive review. <em>Adv Ther<\/em>. 2023;40(9):3697-3722.<\/li>\n<li>Kasper B et al. Desmoid Tumor Working Group. Current management of desmoid tumors: a review. [supplementary appendix] <em>JAMA Oncol<\/em>. 2024;10(8):1121-1128.<\/li>\n<li>Smolle MA et al. Diagnosis and treatment of soft-tissue sarcomas of the extremities and trunk. <em>EFORT<\/em> <em>Open Rev<\/em>. 2017;2(10):421-431.<\/li>\n<li>Carlson JW et al. Immunohistochemistry for \u03b2-catenin in the differential diagnosis of spindle cell lesions: analysis of a series and review of the literature. <em>Histopathology<\/em>. 2007;51(4):509-514.<\/li>\n<li>Penel N et al. Adult desmoid tumors: biology, management and ongoing trials. <em>Curr Opin Oncol<\/em>. 2017;29(4):268-274.<\/li>\n<\/ol>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Raccomandazioni delle linee guida Diagnosi differenziale Strategie diagnostiche Diagnosi Raccomandazioni delle linee guida Collaborare con gli specialisti pu\u00f2 migliorare la prognosi e la qualit\u00e0 della vita dei pazienti1,2 Linee guida DTWG\u2020* \u201cAl momento della diagnosi iniziale, si consiglia di inviare il paziente a team multidisciplinari esperti, per ottenere una consulenza ottimale sulla sicurezza di una&hellip;<\/p>\n","protected":false},"author":9,"featured_media":0,"parent":0,"menu_order":5,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-21939","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Tumori desmoidi: Diagnosi | SpringWorks Therapeutics<\/title>\n<meta name=\"description\" content=\"Esplora le strategie diagnostiche e le raccomandazioni basate su linee guida per il coinvolgimento di team multidisciplinari con competenze ed esperienza nell\u2019ambito dei tumori desmoidi.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.desmoidtumours.eu\/it\/diagnosi\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" 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